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A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
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Plants as Antileishmanial Agents: Current Scenario.

Nazif Ullah1, Akhtar Nadhman2, Sumaira Siddiq1

  • 1Department of Biotechnology, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, Mardan, Pakistan.

Phytotherapy Research : PTR
|October 6, 2016
PubMed
Summary

Natural products offer promising alternatives for treating leishmaniasis, a parasitic disease. This review highlights plant extracts and traditional remedies with antileishmanial effects, addressing drug resistance and toxicity concerns.

Keywords:
antileishmanialleishmaniamedicinal plantsnatural products

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Area of Science:

  • Pharmacology
  • Parasitology
  • Ethnobotany

Background:

  • Leishmaniasis is a significant parasitic disease caused by Leishmania parasites.
  • Existing treatments face challenges due to drug resistance and adverse side effects.
  • Natural products, particularly plant-derived compounds, are explored for their therapeutic potential.

Purpose of the Study:

  • To review the antileishmanial activity of natural products, including plant extracts and traditional remedies.
  • To assess the efficacy of these natural agents against Leishmania parasites.
  • To identify promising compounds for further development.

Main Methods:

  • A systematic literature review was conducted using multiple databases.
  • Studies published between 2000 and 2016 focusing on natural products with antileishmanial activity were analyzed.
  • Data were summarized using tables and graphs.

Main Results:

  • Numerous plant extracts and purified compounds exhibit antileishmanial activity.
  • Traditional remedies used by local healers were also documented.
  • Most research focused on in vitro studies using alcoholic extracts and promastigote forms.

Conclusions:

  • Natural products represent a valuable source for developing new, selective antileishmanial agents.
  • Further in vivo studies and mechanistic investigations are needed to advance promising compounds to clinical application.
  • There is a need to explore natural product activity against Leishmania within host macrophages.