Related Experiment Video
Updated: Mar 14, 2026

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
Modelling hospital length of stay using convolutive mixtures distributions
Adrien Ickowicz1, Ross Sparks1
1CSIRO, Hobart, 7004, TAS, Australia.
Abstract:
Length of hospital stay (LOS) is an important indicator of the hospital activity and management of health care. The skewness in the distribution of LOS poses problems in statistical modelling because it fails to adequately follow the usual traditional distribution of positive variables such as the log-normal distribution. We present in this paper a model using the convolution of two distributions, a technique well known in the signal processing community. The specificity of that model is that the variable of interest is considered to be the resulting sum of two random variables with different distributions. One of the variables features the patient-related factors in terms of their need to recover from their admission condition, while the other models the hospital management process such as the discharging process. Two estimation procedures are proposed. One is the classical maximum likelihood, while the other relates to the expectation-maximization algorithm. We present some results obtained by applying this model to a set of real data from a group of hospitals in Victoria (Australia). Copyright © 2016 John Wiley & Sons, Ltd.
Related Concept Videos
Compartment Models: Single-Compartment Model
Compartment Models: Two-Compartment Model
Noncompartmental Analysis: Mean Residence Time
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
Multicompartment Models: Overview
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Model Approaches for Pharmacokinetic Data: Compartment Models
Two primary types of compartment models are recognized: mammillary and catenary. The more...