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Quercetin suppresses lung cancer growth by targeting Aurora B kinase

Zhu Xingyu1, Ma Peijie2, Peng Dan3

  • 1Department of Respiratory, The Second Affiliated Hospital to Shanxi College of Traditional Chinese Medicine, Xianyang, 712000, China.

Cancer Medicine
|October 6, 2016
PubMed

Insights

Quercetin, an antitumor agent, inhibits aurora B kinase activity by direct binding. This finding suppresses lung cancer cell growth in vitro and in vivo, highlighting quercetin as a potential therapeutic for cancer.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Aurora B kinase is overexpressed in various cancers, promoting tumor development.
  • Targeting aurora B kinase is a promising strategy for cancer drug development.
  • Quercetin is recognized for its antitumor properties.

Purpose of the Study:

  • To investigate the inhibitory effect of quercetin on aurora B kinase.
  • To elucidate the mechanism of quercetin's action against aurora B kinase.
  • To evaluate the efficacy of quercetin as an aurora B kinase inhibitor in lung cancer models.

Main Methods:

  • In vitro and in vivo binding assays to assess quercetin-aurora B interaction.
  • Ex vivo studies using JB6 Cl41 and A549 lung cancer cells.
  • Gene knockdown experiments to evaluate the role of aurora B.
  • In vivo studies in A549 tumor-bearing mice.

Main Results:

  • Quercetin directly binds to and inhibits aurora B kinase activity.
  • Quercetin demonstrated inhibitory effects on aurora B kinase in JB6 Cl41 and A549 cells.
  • Knockdown of aurora B reduced A549 cell sensitivity to quercetin.
  • Quercetin administration suppressed tumor growth in mice and decreased histone 3 phosphorylation.

Conclusions:

  • Quercetin acts as a direct inhibitor of aurora B kinase.
  • Quercetin exhibits anti-lung cancer effects both in vitro and in vivo.
  • Quercetin's inhibition of aurora B kinase is a key mechanism for its antitumor activity.
Keywords:
aurora Binhibitorlung cancer cellsquercetin

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