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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
Depressive Symptoms Contribute to Executive Deficits in Temporal Lobe Epilepsy
Rachel Galioto1, Geoffrey Tremont1, Andrew S Blum1
1From the Warren Alpert Medical School of Brown University, Providence, R.I. (RG, GT, JD); and Rhode Island Hospital, Providence, R.I. (RG, GT, ASB, WCL, JD).
Abstract:
This study examined the contribution of depression to reduced executive functioning in temporal lobe epilepsy (TLE) using three groups: TLE only (TLE; N=29), TLE+depression (TLE+DEP) (N=22), and nonneurologic participants with depression (DEP; N=31). Participants completed the Delis-Kaplan Executive Function System. Individuals with TLE performed worse than the DEP group on many tests of executive functions. Among the TLE participants, those with depression demonstrated poorer executive functioning. These findings support the notion that depression may further contribute to executive difficulties in individuals with TLE. Depression treatment in this population could lead to improvements in cognition.
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