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Updated: Mar 14, 2026

Observational Fear as a Model of Affective Empathy in Mice
Published on: November 22, 2024
Acetaminophen study yields new insights into neurobiological underpinnings of empathy
John Tully1, Marija M Petrinovic2,3
1Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; and.
Abstract:
Empathy is a cornerstone of social behavior, impairments of which are characteristic of neuropsychiatric disorders such as autism and psychopathy. According to the "shared representations" theory, empathy relies on neural processes similar to those underpinning the first-hand experience of a given emotion. A recent study by Mischkowski, Crocker, and Way (Soc Cogn Affect Neurosci 11: 1345-1353, 2016) provides novel insights into neurobiological underpinnings of empathy by demonstrating that acetaminophen, a widely used painkiller, reduces empathy for other's physical and social pain.
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