Densely Packed Microgoblet Laser Pairs for Cross-Referenced Biomolecular Detection

Area of Science:

• Optoelectronics
• Biomedical Engineering
• Nanotechnology

Background:

• On-chip sensing requires high sensitivity and specificity.
• Environmental fluctuations (refractive index, temperature) challenge biosensor accuracy.
• Micro-lasers offer potential for miniaturized and sensitive detection platforms.

Purpose of the Study:

• To present microgoblet laser pairs for cross-referenced on-chip biomolecular sensing.
• To demonstrate parallel readout for enhanced signal fidelity.
• To showcase adaptable chemical sensing through surface functionalization.

Main Methods:

• Fabrication of microgoblet laser pairs.
• Implementation of parallel readout architecture.
• Selective surface functionalization using aligned microcontact stamping.
• Cross-referenced detection of target biomolecules.

Main Results:

• Demonstrated effective mutual filtering of refractive index and temperature fluctuations.
• Achieved cross-referenced detection of two distinct protein types.
• Showcased complete chemical transducer reconfiguration.
• Verified high spatial accuracy in selective surface functionalization.

Conclusions:

• Microgoblet laser pairs provide a robust platform for accurate on-chip biomolecular sensing.
• Parallel readout significantly improves sensor performance by mitigating noise.
• The system allows for multiplexed detection and versatile chemical sensing applications.