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PXR variants: the impact on drug metabolism and therapeutic responses

C Trent Brewer1, Taosheng Chen1

  • 1Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Acta Pharmaceutica Sinica. B
|October 7, 2016
PubMed

Keywords:
AF, activating functionBAMCA, bacterial artificial chromosome array–based methylated CpG island amplificationCYP, cytochrome P450Drug metabolismGST, glutathione S-transferaseMDR, multidrug resistance proteinNHR, nuclear hormone receptorP-gp, P-glycoproteinPXR1, PXR transcript variant 1 (434 residues)PXR2, transcript variant 2 (473 residues)PXR3, transcript variant 3 (397 residues)PXR4, transcript variant 4 (322 residues;AK122990)Pregnane X receptorRACE, 5′ rapid amplification of cDNA endsTherapeutic responsesToxicityTranscript variantsUGT, UDP-glucuronosyltransferaseUTR, untranslated regionshRNA, short hairpin RNAsiRNA, small interfering RNA

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