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Updated: Mar 14, 2026
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Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
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A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors
Jieon Lee1, Il-Soo Park1, Ginam Park1
1Center for RNA Research, Institute for Basic Science, Department of Chemistry, Seoul National University, Seoul, 151-747, Korea. dalheemin@snu.ac.kr.
Chemical Communications (Cambridge, England)
|October 7, 2016
Abstract:
We present a new platform for multiplexed protein kinase activity assay using TiO2 decorated graphene oxide (GO), which is applicable to high throughput inhibitor screening. On the basis of the strong affinity of TiO2 for the phosphate group and the fluorescence quenching capability of GO, phosphorylation of substrates by protein kinases was quantitatively measured in a short time.
