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Quantitative Systems Pharmacology: A Case for Disease Models.
C J Musante1, S Ramanujan2, B J Schmidt3
1Pfizer Inc, Cambridge, Massachusetts, USA.
Quantitative systems pharmacology (QSP) offers innovative model-informed drug discovery and development. Disease-scale platform QSP models provide unique, reusable value for diverse clinical decisions, distinct from other strategies.
Area of Science:
- Pharmacometrics
- Systems Pharmacology
- Drug Development
Background:
- Quantitative systems pharmacology (QSP) is an innovative approach in drug discovery and development.
- QSP models support program decisions from early research to late-stage clinical trials.
Purpose of the Study:
- Discuss the unique value of disease-scale "platform" QSP models.
- Highlight their amenability to reuse and repurposing for diverse clinical decisions.
Main Methods:
- Commentary discussing the application and benefits of QSP models.
- Comparison of platform QSP models with other pharmacometrics strategies.
Main Results:
- Platform QSP models offer distinct advantages over traditional pharmacometrics approaches.
- These models are highly adaptable for reuse and repurposing across various clinical decision-making scenarios.
Conclusions:
- Disease-scale platform QSP models represent a significant advancement in model-informed drug development.
- Their unique characteristics enable broader application and enhanced decision support throughout the drug development lifecycle.
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