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Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Updated: Mar 14, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
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Stem cells and colorectal carcinogenesis.

M Stoian1, V Stoica1, G Radulian2

  • 1"Carol Davila" University of Medicine and Pharmacy, Bucharest; Internal Medicine Department, "Dr. Ion Cantacuzino" Clinical Hospital, Bucharest, Romania.

Journal of Medicine and Life
|October 8, 2016
PubMed
Summary
This summary is machine-generated.

Colorectal cancer stem cells, responsible for tumor recurrence and resistant to conventional treatments, present a promising target for novel therapeutic strategies. Understanding their role is crucial for developing more effective colorectal cancer treatments.

Keywords:
colorectal cancerstem cellstumor markers

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Area of Science:

  • Oncology
  • Gastroenterology
  • Cell Biology

Background:

  • Colorectal cancer (CRC) remains a significant cause of mortality, with its complex pathophysiology still under investigation.
  • Tumor development is multifactorial, involving various conditions rather than a single cause.
  • Adult colonic stem cells and their microenvironment are implicated in CRC development and progression.

Purpose of the Study:

  • To explore the role of adult colonic stem cells in colorectal cancer (CRC) carcinogenesis.
  • To highlight the potential of targeting stem cells for CRC treatment due to their role in recurrence and treatment resistance.

Main Methods:

  • Review of existing theories on colorectal cancer (CRC) carcinogenesis.
  • Analysis of the role of adult colonic stem cells in tumor regeneration and recurrence.
  • Examination of stem cell resistance to chemotherapy and radiotherapy.

Main Results:

  • A small fraction (less than 1%) of neoplastic cells within colon tumors possess tumor-regenerating capabilities, identified as stem cells.
  • These stem cells are strongly associated with tumor recurrence.
  • Colorectal cancer stem cells exhibit inherent resistance to standard chemotherapy and radiotherapy.

Conclusions:

  • Mutations in adult colonic stem cells are postulated to initiate neoplastic changes, driving CRC development.
  • Colorectal cancer stem cells are critical drivers of tumor recurrence and therapeutic resistance.
  • Novel therapeutic strategies targeting these stem cells are essential for improving CRC treatment outcomes.