Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

First Impression01:09

First Impression

328
First impressions play a crucial role in social perception, shaping how individuals assess others in professional, academic, and interpersonal contexts. Psychological research highlights the significance of cognitive biases, such as the primacy and recency effects, which influence how people interpret and recall information.The Primacy Effect and Cognitive AnchoringThe primacy effect describes the tendency for initial information to impact judgment disproportionately. When individuals encounter...
328
First Pass Effect01:12

First Pass Effect

10.4K
Presystemic elimination, or the first-pass effect, is the metabolism of drugs that reduces their effective concentration at the site of action. Apart from the first-pass effect, the systemic bioavailability of the drug is also reduced by other factors, including incomplete absorption or chemical degradation of drugs.
Depending on the route of administration, drugs can be metabolized in the liver, intestine, lungs, and vasculature. Orally administered drugs are first absorbed through the...
10.4K
First Order Systems01:21

First Order Systems

470
First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
470
Serial Position Effect01:03

Serial Position Effect

633
The serial position effect is a cognitive phenomenon where individuals are more likely to recall the first and last items in a list compared to those in the middle. This effect is divided into the primacy effect and the recency effect. The primacy effect is observed when the initial items in a list are remembered better. This occurs because these items are rehearsed more frequently or receive more elaborative processing, allowing them to be encoded into long-term memory more effectively. For...
633
Imprinting01:22

Imprinting

11.4K
Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
11.4K
First-Order Circuits01:15

First-Order Circuits

5.3K
First-order electrical circuits, which comprise resistors and a single energy storage element - either a capacitor or an inductor, are fundamental to many electronic systems. These circuits are governed by a first-order differential equation that describes the relationship between input and output signals.
One common example of a first-order circuit is the RC (resistor-capacitor) circuit. These circuits are used in relaxation oscillators such as neon lamp oscillator circuits. When voltage is...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Risk-Based Isolation Strategy for MDR-Endemic Facilities with Limited Resources.

Infectious disease reports·2026
Same author

Evaluation of Clinical Course and Outcomes of Severe Sepsis and Septic Shock in Elderly Patients.

Journal of clinical practice and research·2025
Same author

Impact of Wars and Disasters on Tuberculosis Epidemiology.

Journal of clinical practice and research·2025
Same author

Sepsis in elderly patients: investigation of prognostic factors in a secondary healthcare facility.

BMC infectious diseases·2025
Same author

Epidemiology and prognosis of sepsis in cancer patients: A multicenter prospective observational study.

The American journal of the medical sciences·2025
Same author

Risk factors and mortality rates of carbapenem-resistant Gram-negative bacterial infections in intensive care units.

Journal of intensive medicine·2024
Same journal

Towards haplotypes of blood group genes: the impact of long-read sequencing in molecular immunohematology.

Annals of translational medicine·2026
Same journal

Development of pharmacological interventions for the treatment of sarcopenia.

Annals of translational medicine·2026
Same journal

Fertility preservation in young women with breast cancer: a narrative review of effectiveness, oncologic safety, and clinical practice implications.

Annals of translational medicine·2026
Same journal

Propofol-based total intravenous anesthesia and recurrence-free survival after hepatectomy-does it improve outcomes?

Annals of translational medicine·2026
Same journal

Is pulmonary hypertension still a contraindication for lung volume reduction?-a narrative review of contemporary evidence.

Annals of translational medicine·2026
Same journal

Calcium montmorillonite clay: a clinically oriented narrative review of emerging perioperative and supportive applications.

Annals of translational medicine·2026
See all related articles

Related Experiment Video

Updated: Mar 14, 2026

A Treatment Package without Escape Extinction to Address Food Selectivity
04:23

A Treatment Package without Escape Extinction to Address Food Selectivity

Published on: August 21, 2015

12.2K

Right first time!

Emine Alp1

  • 1Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Annals of Translational Medicine
|October 8, 2016
PubMed
Summary
This summary is machine-generated.

Early diagnosis and prompt antimicrobial therapy are crucial for improving survival rates in septic shock patients. Optimizing antibiotic dosing based on patient factors and controlling infection sources are essential for better clinical outcomes in intensive care units.

Keywords:
Septic shockantibioticde-escalationpharmacodynamics (PD)pharmacokinetics (PK)

More Related Videos

Recording Single Neurons' Action Potentials from Freely Moving Pigeons Across Three Stages of Learning
11:20

Recording Single Neurons' Action Potentials from Freely Moving Pigeons Across Three Stages of Learning

Published on: June 2, 2014

12.5K
Generating Strictly Controlled Stimuli for Figure Recognition Experiments
05:39

Generating Strictly Controlled Stimuli for Figure Recognition Experiments

Published on: March 18, 2019

5.6K

Related Experiment Videos

Last Updated: Mar 14, 2026

A Treatment Package without Escape Extinction to Address Food Selectivity
04:23

A Treatment Package without Escape Extinction to Address Food Selectivity

Published on: August 21, 2015

12.2K
Recording Single Neurons' Action Potentials from Freely Moving Pigeons Across Three Stages of Learning
11:20

Recording Single Neurons' Action Potentials from Freely Moving Pigeons Across Three Stages of Learning

Published on: June 2, 2014

12.5K
Generating Strictly Controlled Stimuli for Figure Recognition Experiments
05:39

Generating Strictly Controlled Stimuli for Figure Recognition Experiments

Published on: March 18, 2019

5.6K

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Septic shock remains a significant cause of mortality in intensive care units (ICUs), with death rates exceeding 40% despite treatment.
  • High mortality is strongly linked to delayed appropriate antimicrobial therapy.
  • Effective management necessitates early diagnosis and identification of the infection's origin.

Approach:

  • Focus on early diagnosis and source identification for optimal therapeutic management.
  • Implement source control strategies to manage the infection effectively.
  • Optimize antibiotic dosing by considering pharmacokinetic/pharmacodynamic (PK/PD) properties and patient organ dysfunction.

Key Points:

  • Timely initiation of antimicrobial therapy is critical in septic shock.
  • Identifying and controlling the infectious source is paramount.
  • Personalized antibiotic dosing, guided by PK/PD principles and patient status, improves outcomes.

Conclusions:

  • Early and accurate diagnosis, coupled with appropriate antimicrobial treatment and source control, can reduce septic shock mortality.
  • Tailoring antibiotic therapy based on PK/PD and patient-specific factors is vital for clinical success.