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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
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Exercise-induced changes in left ventricular global longitudinal strain in asymptomatic severe aortic stenosis
Agnieszka K Lech1, Piotr P Dobrowolski, Anna Klisiewicz
1Department of Congenital Heart Disease, Institute of Cardiology, Warsaw-Anin, Poland. alech@ikard.pl.
Kardiologia Polska
|October 8, 2016
Summary
In patients with asymptomatic severe aortic stenosis, global longitudinal strain (GLS) indicates early left ventricular (LV) myocardial damage. Exercise reveals preserved but reduced LV functional reserve in these patients.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Mechanics
Background:
- Management of asymptomatic severe aortic stenosis (ASAS) requires identifying early left ventricular (LV) dysfunction.
- Assessing LV function parameters is crucial for timely intervention in ASAS patients.
Purpose of the Study:
- To evaluate exercise-induced changes in LV global longitudinal strain (GLS) in patients with ASAS.
- To determine if GLS can serve as an early marker of myocardial damage in ASAS.
Main Methods:
- Echocardiographic stress tests were performed on 50 ASAS patients and 21 controls.
- LV global longitudinal strain (GLS) was assessed using speckle tracking imaging.
- LV mass index (LVMI) and ejection fraction (LVEF) were analyzed.
Main Results:
- ASAS patients exhibited higher LV mass index (LVMI) and LVEF compared to controls.
- Resting GLS was within normal limits but significantly higher in controls.
- Exercise-induced GLS increase was lower in ASAS patients, suggesting reduced functional reserve.
Conclusions:
- GLS is a non-invasive marker of early LV myocardial damage and hypertrophy in ASAS.
- Exercise-induced GLS changes indicate preserved but diminished LV functional reserve in ASAS.
- Further research is needed to establish the clinical utility of exercise-induced GLS in ASAS management.
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