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Out of Many, One: Computational Reconstruction of Mouse Skin using Single-Cell Transcriptomics
James C Chen1, Angela M Christiano2
1Department of Dermatology, Columbia University, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA.
Cell Stem Cell
|October 8, 2016
Abstract:
Mammalian skin is a complex and heterogeneous tissue with several distinct compartments and stem cell populations. Joost et al. (2016) now use single-cell RNaseq to comprehensively reconstruct this complexity, revealing spatial and pseudotemporal differences between transcriptional programs in distinct compartments and a common basal program in skin stem cell populations.
