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Direct Current Stimulation Alters Neuronal Input/Output Function.

Belen Lafon1, Asif Rahman1, Marom Bikson1

  • 1Department of Biomedical Engineering, The City College of the City University of New York, New York, NY, USA.

Brain Stimulation
|October 9, 2016
PubMed
Summary
This summary is machine-generated.

Direct current stimulation (DCS) alters neuronal input/output functions by changing firing probability. Anodal DCS enhances neuronal excitability, while cathodal DCS shows weaker effects, explaining observed stimulation asymmetries.

Keywords:
DCSElectrical stimulationExcitabilityInput-outputTwo-compartment modeltDCS

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Electrophysiology

Background:

  • Direct current stimulation (DCS) influences neuronal firing rate and synaptic efficacy.
  • The neuronal input/output (I/O) function describes the probability of action potential generation based on synaptic input strength.
  • Previous studies suggest DCS modulates neuronal I/O functions, but direct assessment is lacking.

Purpose of the Study:

  • To investigate the impact of DCS on the neuronal input/output function.
  • To elucidate the mechanisms by which DCS modulates neuronal excitability.

Main Methods:

  • Experiments were conducted using rat hippocampal brain slices.
  • Computational modeling was employed to analyze DCS effects on neuronal I/O functions.

Main Results:

  • DCS was shown to modulate the likelihood of neuronal firing for a fixed synaptic input.
  • Anodal stimulation exhibited synergistic effects, increasing synaptic driving force and somatic spiking probability.
  • Cathodal stimulation showed opposing effects that largely canceled, leading to an asymmetry in stimulation polarity.

Conclusions:

  • The findings demonstrate that DCS directly alters neuronal I/O functions.
  • The observed asymmetry in DCS effects may explain asymmetries in transcranial direct current stimulation outcomes.