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Manufacturing Methods for Liposome Adjuvants.

Yvonne Perrie1,2, Elisabeth Kastner3, Swapnil Khadke4

  • 1Schol of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK. y.perrie@aston.ac.uk.

Methods in Molecular Biology (Clifton, N.J.)
|October 9, 2016
PubMed
Summary

Liposomes are effective vaccine adjuvants, but manufacturing challenges limit their use. This chapter explores current and novel methods for scalable, cost-effective liposomal adjuvant production.

Keywords:
AdjuvantsDelivery systemLiposomesManufacturingPreparationSubunit vaccine

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Area of Science:

  • Biotechnology
  • Vaccinology
  • Materials Science

Background:

  • Liposomes are versatile carriers for vaccine antigens due to their amphiphilic nature.
  • Incorporation of antigens can occur within the lipid bilayer, on the surface, or in the core.
  • Current manufacturing methods for liposomal adjuvants are limited, impacting cost, supply, and scalability.

Purpose of the Study:

  • To review existing manufacturing processes for liposomal adjuvants.
  • To introduce novel manufacturing techniques for improved liposome production.
  • To address challenges in cost, supply, and large-scale application of liposomal adjuvants.

Main Methods:

  • Exploration of established liposome manufacturing techniques.
  • Investigation of innovative methods for rapid and scalable production.
  • Analysis of cost-effectiveness in liposomal adjuvant synthesis.

Main Results:

  • Identification of limitations in current liposome production.
  • Presentation of new manufacturing approaches offering enhanced speed and scalability.
  • Demonstration of potential for cost-effective production of liposomal adjuvants.

Conclusions:

  • Novel manufacturing methods can overcome limitations in current liposomal adjuvant production.
  • Scalable and cost-effective liposome synthesis is achievable.
  • Advancements in manufacturing will facilitate wider application of liposomal adjuvants in vaccines.