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Updated: Mar 14, 2026

In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus
Published on: April 28, 2023
Bolus feeding has no effect on cerebral hemodynamics, irrespective of gestational age
Stefano Bembich1, Gabriele Cont1, Jenny Bua1
1a Institute for Maternal and Child Health IRCCS "Burlo Garofolo" , Trieste , Italy.
Objective:
By multichannel near-infrared spectroscopy, we studied if gestational age has any influence on preterm cerebral hemodynamics, during bolus feeding.
Methods:
Oxy-haemoglobin (HbO2), as cerebral blood flow estimate, and the ratio between HbO2 and total haemoglobin (HbO2/HbTot), as cerebral oxygenation estimate, were assessed in 40 stable premature infants, during a 10 min bolus feeding.
Results:
We found no effect of any of the gestational ages studied (25-34 weeks) either on cerebral blood flow or on oxygenation, during a bolus feeding procedure.
Conclusions:
Bolus feeding appears not to affect cerebral hemodynamics of uncritically preterm infants, irrespective of gestational age.
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