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Related Experiment Video

Updated: Jul 1, 2026

Neonatal Pial Surface Electroporation

Neonatal Pial Surface Electroporation

Published on: May 7, 2014

Drying Very Preterm Infants Before Plastic Wrapping at Birth: A Randomized Clinical Trial.

Francesco Cavallin¹, Nicoletta Doglioni², Francesco Maria Risso³

¹Independent statistician, Solagna, Italy.

JAMA Network Open

|March 3, 2026

Summary

This summary is machine-generated.

Drying preterm infants before plastic wrapping does not improve normothermia rates upon NICU admission. Thermal management remains a critical challenge for these vulnerable newborns, requiring further research.

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Area of Science:

Neonatology
Perinatal care
Thermoregulation

Background:

Maintaining thermal stability in preterm infants immediately after birth is a persistent challenge despite advancements in neonatal care.
Effective thermal management strategies are crucial for improving outcomes in very preterm infants.

Purpose of the Study:

To compare the efficacy of two thermal management strategies: plastic wrapping with drying versus plastic wrapping without drying.
To assess the impact of these strategies on preventing heat loss in very preterm infants at birth.

Main Methods:

A multicenter, unblinded, randomized clinical trial involving very preterm infants (birth weight <1500 g or gestational age ≤30 weeks 6 days).
Infants were randomized to either drying before plastic wrapping or plastic wrapping without drying in the delivery room.
The primary outcome was normothermia (36.5-37.5 °C) at neonatal intensive care unit (NICU) admission.

Main Results:

Normothermia at NICU admission was similar between the dried (45.8%) and undried (46.3%) groups (risk ratio, 0.99; 95% CI, 0.79-1.24).
Mean temperatures at NICU admission were also comparable: 36.4 °C (dried) vs. 36.5 °C (undried).
In-hospital mortality was higher in the dried group (14.7%) compared to the undried group (5.6%).

Conclusions:

Drying very preterm infants before plastic wrapping does not improve normothermia rates upon NICU admission.
Thermal management remains a significant challenge for very preterm infants, with approximately half outside the normal temperature range at NICU admission.
Further research is needed to identify optimal thermal management strategies for this vulnerable population.