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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Association Between Gout and Aortic Stenosis

Kevin Chang1, Chio Yokose1, Craig Tenner2

  • 1Section of Rheumatology, Department of Medicine, Veterans Affairs New York Harbor Healthcare System; Division of Rheumatology, Department of Medicine, New York University School of Medicine; TRIAD (Translational Research in Inflammation and Atherosclerotic Disease), New York University School of Medicine.

The American Journal of Medicine
|October 11, 2016
PubMed

Insights

Gout patients showed a higher prevalence of aortic stenosis than those without gout. Further research is needed to determine if gout is a risk factor or marker for aortic stenosis development.

Area of Science:

  • Cardiology
  • Rheumatology
  • Epidemiology

Background:

  • Gout's association with coronary artery disease is known.
  • The link between gout and valvular heart disease, specifically aortic stenosis, is not well understood.

Purpose of the Study:

  • To investigate the association between gout and the presence of aortic stenosis.

Main Methods:

  • A retrospective case-control study was conducted.
  • Aortic stenosis cases were identified from transthoracic echocardiography (TTE) reports.
  • Gout diagnoses were reviewed in cases and age-matched controls.

Main Results:

  • Aortic stenosis patients had a significantly higher prevalence of gout (21.4%) compared to controls (12.5%).
  • Gout remained a significant independent predictor of aortic stenosis after multivariate analysis (adjusted OR 2.08).
  • Gout diagnosis typically preceded aortic stenosis diagnosis by approximately 5.8 years.

Conclusions:

  • Patients with aortic stenosis exhibit a higher prevalence of preceding gout.
  • The role of gout as a potential risk factor or marker for aortic stenosis requires further investigation.
  • Future studies exploring gout's role in aortic stenosis pathophysiology may offer therapeutic insights.
Abstract

Keywords:
Aortic stenosisGoutValvular heart disease

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