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PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.
Leena Kovanen1, Kati Donner2, Mari Kaunisto2
1Department of Health, National Institute for Health and Welfare (THL), Helsinki, Finland.
Journal of Affective Disorders
|October 11, 2016
Summary
Genetic variants in CRY2 and protein kinase C delta binding protein (PRKCDBP) are associated with major depressive disorder, suggesting they may be risk factors for the condition.
Area of Science:
- Genetics
- Chronobiology
- Psychiatry
Background:
- Circadian rhythm dysfunctions are implicated in depressive disorders.
- Cryptochrome circadian clocks (CRY1, CRY2) influence mood.
- PRKCDBP and SDPR affect the stability of circadian rhythm regulators.
Purpose of the Study:
- To investigate genetic variants of SDPR, PRKCDBP, CRY1, and CRY2 in relation to depressive disorders.
Main Methods:
- Analysis of 48 single-nucleotide polymorphisms in 5910 Finnish individuals.
- Longitudinal assessment with Munich-Composite International Diagnostic Interview (M-CIDI).
- Logistic regression models controlling for age and gender.
Main Results:
- Confirmed association of CRY2 variants with dysthymia and extended to major depressive disorder.
- Identified novel associations of PRKCDBP rs1488864 with depressive disorders and major depressive disorder.
- Statistical significance achieved with q<0.05 for CRY2 and q<0.02 for PRKCDBP.
Conclusions:
- CRY2 and PRKCDBP variants may serve as risk factors for major depressive disorder.
- These genetic findings could aid in the diagnosis of major depressive disorder.
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