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Updated: Mar 13, 2026
Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Helicobacter pylori infection and colorectal carcinoma risk: A meta-analysis
Yang Zhao1, Xuli Wang2, Yanrong Wang3
1Department of Chinese and Western Medicine, Tianjin Fourth Center Hospital (Tianjin Medical University Fourth Center Clinical College), Tianjin 300140, P.R. China.
Objective:
Helicobacter pylori infection and colorectal cancer risk are not clear. We perform this meta-analysis to further evaluate the association between H. pylori infection and colorectal cancer susceptibility.
Methods:
The databases of CNKI, Wanfang, PubMed, Medline, EMBASE, and HighWire Press were electronic searched by two reviewers independently. The case-control study or cohort study about H. pylori infection and colorectal cancer risk were included in this meta-analysis. The association between H. pylori infection and colorectal cancer risk was evaluated by odds ratio (OR) and corresponding 95% confidence interval (95% CI).
Results:
Fourteen case-control studies related to H. pylori infection and colorectal cancer risk were eventually include in this meta-analysis. The pooled results showed that H. pylori infection slight increase the risk of developing colorectal carcinoma (OR = 1.33, 95% CI: 1.01-1.77, P = 0.05). Moreover, Begg's funnel plot demonstrated no significant publication bias.
Conclusion:
Colorectal carcinoma is associated with H. pylori infection. However, for significant heterogeneity across the studies, this results should be further confirmed by large sample size cohort study.
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