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Updated: Mar 13, 2026

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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
Published on: November 1, 2019
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Nuclease activity as a specific biomarker for breast cancer
Luiza I Hernandez1, Veli Cengiz Ozalp, Frank J Hernandez
1SOMAprobes S.L., Science and Technology Park of Gipuzkoa, San Sebastian, 20009, Spain. luiza@somaprobes.com frank.hernandez@somaprobes.com.
Abstract:
We report on the activity of nucleases derived from cancer cells as a means for specific targeting using nucleic acid probes (substrates). We hypothesize that cancer cells can be differentiated from healthy cells based on their nuclease activity profile, and thus, any method based on this property represents a novel alternative for diagnostic and therapeutic intervention.

