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Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers

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Published on: March 21, 2025

Plasmonically Engineered Nanoprobes for Biomedical Applications.

Amit Kumar¹, Sungi Kim¹, Jwa-Min Nam¹

¹Department of Chemistry, Seoul National University , Seoul 151-747, South Korea.

Journal of the American Chemical Society

|October 11, 2016

Summary

This summary is machine-generated.

Plasmonic engineering creates advanced nanoprobes (PENs) with tunable properties for enhanced biomedical sensing and therapies. These engineered nanoparticles offer significant potential for future medical diagnostics and treatments.

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Area of Science:

Nanotechnology
Biomedical Engineering
Materials Science

Background:

Localized surface plasmon resonance (LSPR) in metal nanoparticles is a key property dependent on composition, morphology, and coupling.
Plasmonic engineering precisely controls nanostructure formation to achieve targeted plasmonic properties like electromagnetic field enhancement.

Purpose of the Study:

To introduce the concept of plasmonic engineering for designing plasmonically engineered nanoprobes (PENs).
To highlight the diverse biomedical applications of PENs, including sensing, imaging, and therapy.
To discuss current challenges and future prospects for PENs in medicine and biotechnology.

Main Methods:

Controlled synthesis, assembly, and atomic/molecular tuning strategies for nanostructure fabrication.
Characterization of PENs' physical, chemical, and biological properties.
Review of recent examples of biomedically functional PENs.

Main Results:

PENs exhibit unique properties such as optical signal enhancement, catalytic activity, and photothermal effects.
PENs enable various biomedical applications: LSPR-based sensing, surface-enhanced Raman scattering (SERS), metal-enhanced fluorescence, photothermal therapy, and photoacoustic imaging.
Demonstrated utility of PENs in biosensing, bioimaging, therapeutic, and theranostic applications.

Conclusions:

Plasmonic engineering is a powerful approach for developing advanced nanoprobes for biomedical use.
PENs offer significant potential for revolutionizing diagnostics, imaging, and therapeutics in medicine.
Further research and development are needed to overcome challenges and realize the full clinical potential of PENs.