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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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Association between MASP-2 gene polymorphism and risk of infection diseases: A meta-analysis

Jie Fu1, Jingqiu Wang2, Yanping Luo2

  • 1Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China; National Hospital of Linxia City, Linxia, 731100, China.

Microbial Pathogenesis
|October 12, 2016
PubMed
Abstract

Insights

This meta-analysis found no link between MASP-2 gene rs72550870 polymorphism and infection disease risk. The study indicates this specific gene variant does not increase susceptibility to infections.

Area of Science:

  • Immunology
  • Genetics

Background:

  • Mannan-binding lectin-associated serine protease 2 (MASP-2) is crucial for lectin pathway complement activation.
  • MASP-2 activation is implicated in the development of infectious diseases.

Purpose of the Study:

  • To investigate the association between MASP-2 functional gene (rs72550870) polymorphism and infection disease risk using a meta-analysis.

Main Methods:

  • A systematic literature search was conducted across multiple databases up to January 2016.
  • Nine case-control studies were included, data extracted, and quality assessed.
  • Statistical analysis was performed using STATA 12.0 software.

Main Results:

  • No significant association was found between MASP-2 rs72550870 polymorphism and infection disease risk under allele or recessive models.
  • Allele model (G vs. A): OR=0.89, 95% CI=0.66-1.21, P=0.445.
  • Recessive model (AG+GG vs. AA): OR=0.88, 95% CI=0.65-1.20, P=0.428.

Conclusions:

  • The MASP-2 rs72550870 polymorphism is not associated with infection diseases.
  • This key functional gene polymorphism does not increase susceptibility to infection diseases.
  • Subgroup analyses by geography and pathogen type showed no significant differences.
Keywords:
ComplementInfection diseasesMBL-Associated serine protease-2Meta-analysisPolymorphism

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