Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.0K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

6.3K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
6.3K
Tissue Membranes01:27

Tissue Membranes

11.4K
A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial...
11.4K
Infection01:20

Infection

13.8K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
13.8K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

10.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
10.5K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative genomics of Sneathia species: insights into pathogenicity and adaptation to the human niche.

BMC microbiology·2026
Same author

Retinal integrity in human babesiosis: a pilot study.

BMC ophthalmology·2024
Same author

A purified reconstituted bilayer matrix shows improved outcomes in treatment of non-healing diabetic foot ulcers when compared to the standard of care: Final results and analysis of a prospective, randomized, controlled, multi-centre clinical trial.

International wound journal·2024
Same author

Predicting pressure injury risk in hospitalised patients using machine learning with electronic health records: a US multilevel cohort study.

BMJ open·2024
Same author

Comparative Effectiveness of Placental Allografts in the Treatment of Diabetic Lower Extremity Ulcers and Venous Leg Ulcers in U.S. Medicare Beneficiaries: A Retrospective Observational Cohort Study Using Real-World Evidence.

Advances in wound care·2024
Same author

Topical pravibismane as adjunctive therapy for moderate or severe diabetic foot infections: A phase 1b randomized, multicenter, double-blind, placebo-controlled trial.

International wound journal·2024

Related Experiment Video

Updated: Mar 13, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.7K

Skin and Soft Tissue Infections.

Anne Spichler Moffarah1, Mayar Al Mohajer2, Bonnie L Hurwitz3

  • 1Department of Medicine, University of Arizona Health Sciences Center, Tucson, AZ 85721.

Microbiology Spectrum
|October 12, 2016
PubMed
Summary

Skin and soft tissue infections (SSTIs) in immunocompromised individuals present diagnostic challenges. This review covers their epidemiology, diagnosis, and management, emphasizing molecular techniques for pathogen identification.

More Related Videos

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
10:45

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

11.3K
A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
08:30

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

Published on: September 16, 2022

2.5K

Related Experiment Videos

Last Updated: Mar 13, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.7K
Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
10:45

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

11.3K
A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
08:30

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

Published on: September 16, 2022

2.5K

Area of Science:

  • Microbiology
  • Immunology
  • Dermatology

Background:

  • The skin hosts a diverse microbiome, but imbalances can lead to infections.
  • Skin and soft tissue infections (SSTIs) are common but challenging to diagnose, especially in immunocompromised patients.
  • These infections can be caused by bacteria, fungi, viruses, mycobacteria, and protozoa.

Purpose of the Study:

  • To review the epidemiology, pathophysiology, and clinical presentation of SSTIs.
  • To highlight diagnostic challenges in immunocompromised hosts.
  • To discuss advanced diagnostic techniques, including molecular methods, for SSTIs.

Main Methods:

  • Literature review focusing on SSTIs in immunocompromised populations.
  • Analysis of diagnostic approaches, including clinical assessment, cultures, histology, and molecular techniques.
  • Examination of epidemiological and pathophysiological data.

Main Results:

  • SSTIs in immunocompromised hosts are complex and can mimic other conditions or systemic diseases.
  • Accurate diagnosis requires a combination of clinical evaluation and microbiological investigations.
  • Molecular techniques offer enhanced pathogen identification for targeted treatment.

Conclusions:

  • Diagnosing SSTIs in immunocompromised patients requires a comprehensive approach.
  • Early and accurate identification of causative agents is crucial for effective treatment.
  • Molecular diagnostics are vital tools for managing complex SSTIs in vulnerable populations.