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Updated: Mar 13, 2026
Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
Published on: May 18, 2015
Development of an oral mucosa equivalent using a porcine dermal matrix
F G Basso1, J Hebling2, C L Marcelo3
1Department of Physiology and Pathology, Araraquara Dental School, UNESP, Araraquara, São Paulo, Brazil.
Abstract:
We evaluated the suitability of a porcine acellular dermal matrix for the development of a 3-dimensional oral mucosal equivalent using an ex vivo-produced oral mucosal equivalent (EVPOME). Oral keratinocytes were seeded in a submerged model, and then in an air-liquid interphase model, using Transwell® inserts. EVPOME showed good cell viability and increased glucose consumption over time. Histological evaluation showed that stratified differentiated epithelium had formed in all matrices.
