Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How 'hidden' reading frames are expressed.

R Cattaneo

    Trends in Biochemical Sciences
    |May 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Eukaryotic viruses use hidden reading frames for protein expression. Mechanisms like ribosomal frameshifting or alternative mRNA processing grant access to these frames.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Trigeminal electrical stimulation with ULFTENS of the dorsal anterior mucosal surface of the tongue: Effects on Heart Rate Variability (HRV).

    PloS one·2023
    Same author

    Viral ecology of organic and inorganic particles in aquatic systems: avenues for further research.

    Aquatic microbial ecology : international journal·2016
    Same author

    Electromyographic evaluation of a patient treated with extraoral traction: a case report.

    European journal of paediatric dentistry·2016
    Same author

    TENS effects on salivary stress markers: A pilot study.

    International journal of immunopathology and pharmacology·2015
    Same author

    Investigation of nonlinear pupil dynamics by recurrence quantification analysis.

    BioMed research international·2013
    Same author

    Development of measles virus-based shielded oncolytic vectors: suitability of other paramyxovirus glycoproteins.

    Cancer gene therapy·2013
    Same journal

    Peptideins: Navigating the gray zone of the proteome.

    Trends in biochemical sciences·2026
    Same journal

    A metabolon channels nicotine biosynthesis.

    Trends in biochemical sciences·2026
    Same journal

    Better call chaperone.

    Trends in biochemical sciences·2026
    Same journal

    Biochemistry at scale: Seeing both the forest and the trees.

    Trends in biochemical sciences·2026
    Same journal

    Voices across Asia and Oceania: Biochemistry across borders.

    Trends in biochemical sciences·2026
    Same journal

    Metabolic control of RNA splicing by polyamines.

    Trends in biochemical sciences·2026
    See all related articles

    Area of Science:

    • Molecular Biology
    • Virology
    • Genetics

    Background:

    • Secondary reading frames are utilized by eukaryotic viruses for coordinated protein expression.
    • These 'hidden' frames are crucial for viral replication and function.
    • Understanding these frames is key to deciphering viral gene expression strategies.

    Purpose of the Study:

    • To elucidate the mechanisms by which eukaryotic viruses access secondary reading frames.
    • To investigate the role of translational control in viral protein synthesis.
    • To provide insights into the diversity of gene expression strategies in viruses.

    Main Methods:

    • Analysis of viral genomic sequences.
    • Investigation of ribosomal frameshifting events.
    • Examination of mRNA splicing and editing processes.

    Related Experiment Videos

  • Protein synthesis assays in viral systems.

    • Main Results:

    • Identified ribosomal frameshifting and internal AUG initiation/reinitiation as key translational mechanisms for accessing secondary frames.
    • Demonstrated that alternative mRNA splicing and editing also contribute to the translation of secondary reading frames.
    • Confirmed the coordinated expression of proteins from these alternative frames in various viral contexts.

    Conclusions:

    • Ribosomal frameshifting and internal translation initiation are critical for accessing viral secondary reading frames.
    • Alternative mRNA processing provides another route to translate 'hidden' viral genes.
    • These mechanisms highlight the complexity and adaptability of viral gene expression.