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Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...

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Related Experiment Video

Updated: Mar 13, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Using FlyBase, a Database of Drosophila Genes and Genomes.

Steven J Marygold¹, Madeline A Crosby², Joshua L Goodman³

¹Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK. sjm41@cam.ac.uk.

Methods in Molecular Biology (Clifton, N.J.)

|October 13, 2016

Summary

This summary is machine-generated.

FlyBase, a Drosophila melanogaster research database, has been updated with new features and community initiatives to integrate vast biological data. These improvements enhance data exploration and accelerate scientific discovery for researchers.

Keywords:

Database Drosophila FlyBase Genetics Genomics Translational research

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Area of Science:

* Genomics and proteomics research
* Model organism databases
* Bioinformatics and computational biology

Background:

* FlyBase has served as a primary resource for Drosophila melanogaster research for nearly 25 years.
* Advances in high-throughput technologies necessitate integrated data management for genomic and proteomic information.
* A centralized view of Drosophila research is crucial for efficient scientific progress.

Observation:

* New reagent types and physical interaction data are now available through novel report pages.
* Dedicated Human Disease Model Reports showcase Drosophila models of human diseases.
* Integrated reports consolidate related genes, datasets, and reagents for comprehensive analysis.

Findings:

* Gene Reports have been revised for improved access to functional data and new data types.
* External links have been expanded and organized for better resource navigation.
* New tools facilitate data interrogation, including batch processing and bulk file availability.

Implications:

* Enhanced data integration and accessibility in FlyBase accelerate research in Drosophila genetics and human disease modeling.
* Community-driven initiatives foster stronger researcher-database interaction and feedback loops.
* The updated FlyBase platform empowers efficient exploration of diverse biological data, driving scientific discovery.