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Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients


Daijo Inaguma, Hibiki Shinjo, Akihito Tanaka

    Clinical Nephrology
    |October 13, 2016
    PubMed

    Insights

    Lower serum 1,25-dihydroxyvitamin D (1,25D) levels correlate with larger left atrial diameter (LAD) in pre-dialysis chronic kidney disease (CKD) patients. This association is significant in those with lower left ventricular mass index and preserved ejection fraction.

    Area of Science:

    • Nephrology
    • Cardiology
    • Endocrinology

    Background:

    • Chronic kidney disease (CKD) is associated with cardiovascular complications, including left atrial remodeling.
    • Vitamin D deficiency is common in CKD patients and may play a role in cardiovascular health.

    Purpose of the Study:

    • To investigate the correlation between serum 1,25-dihydroxyvitamin D (1,25D) levels and left atrial diameter (LAD) in pre-dialysis CKD patients.
    • To identify factors influencing LAD in this population.

    Main Methods:

    • A cross-sectional study included 378 patients with CKD stages 3a-5 not on dialysis or transplantation.
    • Serum 1,25D levels and echocardiographic parameters, including LAD, were measured.
    • Stepwise multiple regression analyses were performed to assess the relationship between 1,25D and LAD, controlling for other factors.

    Main Results:

    • Serum 1,25D levels showed a negative correlation with LAD and other cardiac parameters like left ventricular mass index (LVMI).
    • A significant independent relationship was found between lower serum 1,25D levels and increased LAD (regression coefficient = -0.070, p = 0.001).
    • This association remained significant in subgroups with LVMI < 125 g/m² and ejection fraction (EF) ≥ 60%.

    Conclusions:

    • Serum 1,25D levels are independently associated with LAD in pre-dialysis CKD patients.
    • The association between 1,25D and LAD was not significant in patients with EF < 60% or LVMI > 125 g/m².
    • These findings suggest a potential role for vitamin D in left atrial remodeling in CKD.
    Abstract

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