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Updated: Mar 13, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Genetic Basis of Gastric Cancer
Yue-Wen Gao1, Chun-Hua Zhang1, Xing-Mei Zuo1
1Department of Surgery, Rizhao People's Hospital, Rizhao, Shandong 276828, China.
Abstract:
Gastric cancer is the result of multiple risk factors, including environmental factors, genetic factors and the interaction between them. The environmental factors mainly include dietary, Helicobacter pylori infection and family history of gastric cancer. Genetic factors mainly refer to the susceptible genes that cause epigenetic alterations in oncogenes, tumor suppress genes, cell cycle regulators, DNA repair genes and signaling molecules. This paper summarizes the susceptible genes of gastric cancer and explores the genetic basis of it.
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