[The effect of surface active substances on the barrier properties of the skin]

It was established in experiments conducted on white rats that application to the skin of sulphonol and cintamide--5 for a period of three months result in morphological disorders of the ultrastructural organization of the epidermis, especially of the structure of intercellular contacts. A mixture of these substances produces a more severe noxious effect on the structures. These substances produced also a local effect on the skin microcirculation. The authors propose a scheme for explanation of the mechanism of structural-functional changes of the skin in local applications of surface-active substances.