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[Clozapine-induced cholestatic jaundice: a case report]
G Dorta1, R Siebenmann, P Fröhli
1Medizinische Klinik, Stadtspital Triemli, Zürich.
Zeitschrift Fur Gastroenterologie
|July 1, 1989
Summary
Clozapine (Leponex) treatment can cause cholestatic hepatitis, a serious liver condition. Discontinuation of clozapine led to patient recovery and normalized liver function, highlighting a significant side effect.
Area of Science:
- Hepatology
- Pharmacology
- Psychiatry
Background:
- Clozapine is an atypical antipsychotic used for treatment-resistant schizophrenia.
- Antipsychotic medications can have various adverse effects, including hepatic complications.
Observation:
- A patient developed jaundice during clozapine therapy.
- Histological examination revealed cholestatic hepatitis with hepatocyte necrosis and eosinophilic infiltration.
Findings:
- The patient's jaundice and liver function abnormalities resolved within 4 weeks of discontinuing clozapine.
- The observed liver injury pattern is consistent with drug-induced cholestatic hepatitis.
Implications:
- This case suggests clozapine can induce cholestatic hepatitis, similar to phenothiazine antipsychotics.
- Clinicians should monitor liver function in patients receiving clozapine, especially those with risk factors for liver disease.