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Updated: Mar 13, 2026
13:48
Reverse Genetics Mediated Recovery of Infectious Murine Norovirus
Published on: June 24, 2012
17.3K
Norovirus genetic diversity and evolution: implications for antiviral therapy
Joana Rocha-Pereira1, Jana Van Dycke1, Johan Neyts1
1KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Current Opinion in Virology
|October 14, 2016
Summary
Human noroviruses cause widespread foodborne illness. This review discusses norovirus evolution, persistence in immunocompromised individuals, and the potential for antiviral drug resistance.
Area of Science:
- Virology
- Immunology
- Epidemiology
Background:
- Human noroviruses are a primary cause of acute and chronic gastroenteritis globally.
- Recent advancements include vaccine candidates in clinical development and initial antiviral therapy research.
- Understanding norovirus behavior is crucial for public health interventions.
Purpose of the Study:
- To review the genetic evolution of human noroviruses.
- To discuss norovirus persistence in immunocompromised patient populations.
- To assess the risks and consequences of antiviral resistance development.
Main Methods:
- Literature review and synthesis of existing research on norovirus genetics, clinical aspects, and therapeutic development.
- Analysis of factors contributing to norovirus persistence.
- Evaluation of potential mechanisms and implications of antiviral drug resistance.
Main Results:
- Noroviruses exhibit significant genetic diversity and rapid evolution.
- Immunocompromised individuals can experience prolonged norovirus shedding and persistence.
- Antiviral resistance is a plausible concern for future norovirus therapies.
Conclusions:
- Continued monitoring of norovirus evolution is essential.
- Strategies to manage norovirus in immunocompromised hosts require further development.
- Proactive assessment of antiviral resistance is necessary to ensure treatment efficacy.
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