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Updated: Mar 13, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Malignant Transformation of an Aneurysmal Bone Cyst to Fibroblastic Osteosarcoma
Akash P Kansagra, Jennifer J Wan1, Kavi K Devulapalli
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA. jennifer.wan@ucsf.edu.
Abstract:
Aneurysmal bone cysts are uncommon primary bone tumors typically regarded as histologically and clinically benign. Malignant transformation of these lesions occurs almost exclusively in the context of prior radiation exposure. However, 4 cases of an osteosarcoma developing without prior radiation exposure have been reported. In this article, we report a fifth case of degeneration of an aneurysmal bone cyst to a fibroblastic osteosarcoma. In addition to reviewing the earlier cases, we describe the radiologic, pathologic, and immunohistochemical basis of this diagnosis.
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