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Draft Genome Sequence of Streptomyces sp. SPMA113, a Prajinamide Producer

Hisayuki Komaki1, Akira Hosoyama2, Natsuko Ichikawa2

  • 1Biological Resource Center, National Institute of Technology and Evaluation (NBRC), Chiba, Japan komaki-hisayuki@nite.go.jp.

Genome Announcements
|October 15, 2016
PubMed

Insights

We sequenced the genome of Streptomyces sp. SPMA113 from Thailand soil. This bacterium produces prajinamide, a novel peptide with adipocyte differentiation activity, and has potential for diverse metabolite production.

Area of Science:

  • Microbiology
  • Genomics
  • Biochemistry

Background:

  • Streptomyces species are known for producing diverse bioactive secondary metabolites.
  • Soil microorganisms are a rich source of novel compounds with potential therapeutic applications.

Purpose of the Study:

  • To report the draft genome sequence of Streptomyces sp. SPMA113.
  • To identify the biosynthetic potential of this strain for novel secondary metabolites.

Main Methods:

  • Whole-genome sequencing of Streptomyces sp. SPMA113.
  • Bioinformatic analysis of the genome to identify gene clusters responsible for secondary metabolite production.

Main Results:

  • The draft genome sequence of Streptomyces sp. SPMA113 was successfully obtained.
  • The strain produces a new modified peptide, prajinamide, exhibiting adipocyte differentiation activity.
  • The genome contains at least 30 gene clusters for polyketide and nonribosomal peptide synthases, indicating significant biosynthetic capabilities.

Conclusions:

  • Streptomyces sp. SPMA113 is a promising source of novel bioactive compounds.
  • The genetic potential exists for the production of a wide array of secondary metabolites by this strain.

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