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Related Experiment Video

Updated: Mar 13, 2026

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
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Primary Choroid Plexus Tissue for Use in Cellular Therapy.

M A Sandrof1, D F Emerich2, Chris G Thanos3

  • 1Cytosolv, Inc., 117 Chapman Street, Suite 107, Providence, RI, 02905, USA.

Methods in Molecular Biology (Clifton, N.J.)
|October 15, 2016
PubMed
Summary
This summary is machine-generated.

Choroid plexus (CP) cells show therapeutic potential for various conditions due to their regenerative secretome and longevity. Encapsulated CP is being tested in clinical trials for Parkinson's disease and other applications.

Keywords:
AlginateCell transplantationChoroid plexusEncapsulationMicrocapsule

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Area of Science:

  • Cellular therapeutics
  • Regenerative medicine
  • Biomaterials

Background:

  • The choroid plexus (CP) is vital for brain homeostasis and possesses regenerative properties.
  • Its secretome and cellular longevity make it a promising candidate for therapeutic applications.
  • CP-derived therapies could address central nervous system disorders, hearing loss, and chronic wounds.

Purpose of the Study:

  • To summarize recent advancements in choroid plexus (CP) factor delivery.
  • To describe materials and methods for CP-based cellular therapies.
  • To highlight the therapeutic potential of CP in diverse medical indications.

Main Methods:

  • Isolation and purification of CP epithelial cells from animal sources.
  • Culture of CP cells in various three-dimensional configurations with distinct gene expression profiles.
  • Encapsulation of CP epithelial clusters for in vitro and in vivo applications.
  • Topical application of purified CP secretome extracts for wound healing.
  • Development of encapsulated porcine CP for Parkinson's disease treatment.

Main Results:

  • CP cells can be cultured and maintained in encapsulated forms for extended durations with preserved potency.
  • CP secretome exhibits therapeutic effects, particularly in wound healing.
  • Encapsulated porcine CP is under investigation in a Phase I clinical trial for Parkinson's disease.
  • CP epithelium demonstrates adaptability to different microenvironments and culture conditions.

Conclusions:

  • Choroid plexus (CP) cellular therapy holds significant promise for a wide range of diseases.
  • Encapsulation technologies enhance the longevity and potency of CP therapeutics.
  • Further research and clinical trials are warranted to fully realize the therapeutic potential of CP-derived factors.