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New Modalities in Drug Therapy: Modifying Ongoing Chemical Conversations in the Brain
1Department of Pharmacology, University of North Carolina School of Medicine , Chapel Hill, North Carolina 27516, United States.
Abstract:
The modification of ongoing chemical signaling in the brain through allosteric modification of seven transmembrane receptors offers a wealth of diverse beneficial outcomes in drug therapy. Specifically, biased agonism can emphasize beneficial signals and de-emphasize harmful signals thus increasing the effectiveness of agonists and opening up new vistas for previously precluded drug targets. In addition, the modification of natural agonism through positive and negative allostery can provide useful rejuvenation of failing systems.
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