Related Experiment Video

Updated: Aug 21, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

Kinetic Benefit(s) of Allosteric Receptor Blockade by Positive Allosteric Modulator Antagonists

Georges Vauquellin1, Terry Kenakin2

  • 1Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.

ACS Pharmacology & Translational Science
|August 19, 2026
PubMed
Abstract

Keywords:
PAM antagonistsallosteric bindingbinding kineticsreceptor activationsimulationsthermodynamic cycle

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