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Gaucher disease type I and pregnancy.
J Zlotogora1, M Sagi, M Zeigler
1Department of Human Genetics, Hadassah Medical Center, Hebrew University, Jerusalem.
American Journal of Medical Genetics
|April 1, 1989
Summary
Pregnancy in women with Gaucher disease (GD) type I generally proceeds normally, but some may experience disease exacerbation or require blood transfusions. Early pregnancy monitoring is recommended for Gaucher disease patients.
Area of Science:
- Reproductive Medicine
- Genetic Metabolic Disorders
Background:
- Gaucher disease (GD) is a genetic disorder affecting metabolism.
- Pregnancy outcomes in women with GD type I require further investigation.
Purpose of the Study:
- To assess the impact of pregnancy on Gaucher disease type I.
- To evaluate the course and outcomes of pregnancies in women with GD type I.
Main Methods:
- Survey of 47 pregnancies in 17 women diagnosed with Gaucher disease type I.
- Observation of disease progression and pregnancy complications.
Main Results:
- Most pregnancies in women with GD type I were uncomplicated.
- Some patients experienced disease exacerbation during or after pregnancy.
- Six women required blood transfusions; one patient had recurrent spontaneous abortions.
Conclusions:
- Pregnancy in women with Gaucher disease type I carries some risk.
- Close monitoring and planned follow-up from early pregnancy are crucial for these patients.