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Updated: Mar 13, 2026
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"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
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Hepatitis B Virus Infection and Liver Decompensation
Brendon K Luvisa1, Tarek I Hassanein2
1Southern California Research Center, Coronado, CA 92118, USA.
Clinics in Liver Disease
|October 16, 2016
Summary
Effective treatment for immune-active Hepatitis B virus (HBV) infection involves suppressing viral replication to prevent liver disease progression. Highly active antivirals like entecavir and tenofovir are key to achieving this goal.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- Immune-active Hepatitis B virus (HBV) infection poses risks of fibrosis, cirrhosis, liver decompensation, and hepatocellular carcinoma.
- Viral replication must be suppressed to manage disease progression.
Purpose of the Study:
- To outline the therapeutic goals in managing immune-active HBV infection.
- To identify effective antiviral strategies for HBV management and prevention of recurrence post-transplantation.
Main Methods:
- Review of current treatment guidelines for HBV infection.
- Emphasis on the role of specific antiviral agents in clinical practice.
Main Results:
- Entecavir and tenofovir are highly active antivirals recommended as first-line therapy.
- These agents are effective in immune-active HBV and for preventing recurrence after liver transplantation.
Conclusions:
- Achieving significant viral suppression is crucial for preventing severe liver disease outcomes.
- Early initiation of first-line antivirals is recommended for patients with decompensated cirrhosis awaiting transplantation.
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