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Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
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Imaging of Musculoskeletal Infection

Kevin R Math1, Jennifer L Berkowitz1, Stephen A Paget1

  • 1Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.

Rheumatic Diseases Clinics of North America
|October 16, 2016
PubMed

Insights

Diagnostic imaging is key for identifying musculoskeletal (MSK) infections and their severity. Advanced technologies improve accuracy, aiding diagnosis despite challenges like non-specific symptoms and surgical artifacts.

Area of Science:

  • Radiology
  • Orthopedics
  • Infectious Diseases

Background:

  • Musculoskeletal (MSK) infections present diagnostic challenges due to nonspecific symptoms like pain and swelling.
  • Pre-existing conditions and prior surgical hardware can complicate accurate diagnosis via imaging.
  • Certain imaging features are pathognomonic for infection, aiding in diagnosis.

Purpose of the Study:

  • To highlight the critical role of diagnostic imaging in MSK infections.
  • To discuss the challenges in diagnosing MSK infections.
  • To emphasize the impact of technological advancements on diagnostic accuracy.

Main Methods:

  • Review of diagnostic imaging modalities for MSK infections.
  • Analysis of imaging features indicative of infection.
  • Consideration of factors complicating diagnosis, such as prior surgery and patient conditions.

Main Results:

  • Diagnostic imaging is essential for confirming MSK infection and assessing disease extent.
  • Nonspecific clinical presentations and confounding factors (e.g., surgical hardware) pose diagnostic difficulties.
  • Recent technological advancements have significantly enhanced the sensitivity, specificity, and accuracy of MSK infection diagnosis.

Conclusions:

  • Diagnostic imaging is indispensable for managing musculoskeletal infections.
  • Overcoming diagnostic challenges requires understanding imaging nuances and leveraging technological progress.
  • Improved imaging techniques lead to more accurate and timely diagnoses of MSK infections.
Keywords:
Clinical diagnosisDiagnostic imagingMusculoskeletal infection

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