Related Experiment Video

Updated: Mar 13, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.8K

Effects of Percutaneous Transluminal Angioplasty on Diastolic Function in Patients With Chronic Occlusion of

Wonho Kim, Ramon Quesada, Melanie B Schernthaner

  • 1Miami Cardiac and Vascular Institute (MCVI), 8900 N. Kendall Drive, Miami, FL 33176 USA. barryk@baptisthealth.net.

The Journal of Invasive Cardiology
|October 16, 2016
PubMed

Insights

Successful revascularization of chronic total occlusions in large lower-extremity arteries improved left ventricular diastolic function. This suggests afterload reduction benefits cardiac health in these patients.

Area of Science:

  • Cardiology
  • Vascular Surgery
  • Echocardiography

Background:

  • Chronic total occlusions (CTOs) in large lower-extremity arteries may increase systemic vascular resistance and left ventricular (LV) afterload.
  • Elevated LV afterload is a known cause of LV diastolic dysfunction.

Purpose of the Study:

  • To investigate the association between successful revascularization of lower-extremity artery CTOs and improvements in LV diastolic function.
  • To determine if endovascular revascularization impacts echocardiographic measures of diastolic function.

Main Methods:

  • Retrospective analysis of 20 patients with aorto-iliac and femoropopliteal CTOs undergoing successful endovascular revascularization.
  • Baseline and postprocedural echocardiography assessed LV diastolic function.
  • Primary endpoint: improvement in LV diastolic function, defined by changes in E/E' ratio and E' velocity.

Main Results:

  • Successful revascularization significantly improved the E/A ratio (P=.046) due to increased A velocity (P=.03).
  • A significant reduction in the E/E' ratio was observed (P=.02), indicating improved diastolic function.
  • While E' velocity did not significantly increase (P=.07), the overall trend suggested diastolic improvement.

Conclusions:

  • Successful revascularization of large lower-extremity artery CTOs is linked to enhanced LV diastolic function parameters.
  • These echocardiographic improvements may be attributed to the reduction in LV afterload post-revascularization.
Abstract

More Related Videos

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging10:50

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging

Published on: June 29, 2013

12.8K
Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

2.1K

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
494
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
580
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
506
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
549
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
528
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
359