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Biologically active xanthones from Codonopsis ovata.

Alamgir A Dar1, Nisar A Dangroo1, Arun Raina2

  • 1Bioorganic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi, J&K 180001, India.

Phytochemistry
|October 18, 2016
PubMed
Summary
This summary is machine-generated.

Five new xanthones were isolated from Codonopsis ovata, with some showing significant cytotoxic activity against various human cancer cell lines. This study marks the first report of xanthones in this genus.

Keywords:
CampanulaceaeCodonopsis ovataCytotoxicityFlavonoidsSteroidsTriterpenoidsXanthones

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Pharmacology

Background:

  • The genus Codonopsis is known for its traditional medicinal uses.
  • Secondary metabolites from plants are a rich source of potential therapeutic agents.
  • The chemical constituents and biological activities of Codonopsis ovata remain largely unexplored.

Purpose of the Study:

  • To isolate and characterize new secondary metabolites from Codonopsis ovata.
  • To investigate the cytotoxic potential of isolated compounds against a panel of human cancer cell lines.
  • To report the first isolation of xanthones from the genus Codonopsis.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation of new compounds utilizing HRMS, NMR, and ECD spectroscopy.
  • Cytotoxicity evaluation using the SRB assay against A549, PC-3, HCT-116, MCF-7, SF-295, and MDAMB-435 cell lines.

Main Results:

  • Five new xanthones (coxanthones A-E) and 21 known compounds were isolated.
  • Coxanthone B demonstrated significant cytotoxicity against SF-295 and MDAMB-435 cell lines (IC50 7.0 and 15.0 μM).
  • Kaempferol exhibited potent cytotoxic activity across all tested cell lines (IC50 1.0-2.3 μM).
  • New cytotoxic activities were reported for 1-hydroxy-3,5-dimethoxyxanthone, swertiperenine, and 1,7,8-trihydroxy-3-methoxyxanthone.

Conclusions:

  • Codonopsis ovata is a source of novel xanthone derivatives.
  • Several isolated compounds, particularly coxanthone B and kaempferol, show promising cytotoxic effects against human cancer cell lines.
  • This study provides a foundation for further investigation into the anticancer potential of compounds from Codonopsis ovata.