Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

4.0K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
4.0K
The Cell Cycle Control System02:11

The Cell Cycle Control System

14.7K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
14.7K
The Cell Cycle Control System01:28

The Cell Cycle Control System

6.3K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
6.3K
The Cell Cycle Control System02:11

The Cell Cycle Control System

9.1K
9.1K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

5.2K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.2K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

3.2K
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cannabinoid CB<sub>2</sub> receptor drives trastuzumab resistance and predicts durable anti-HER2 response.

Oncogene·2026
Same author

Tumor ecology and the paradox of clean margins in multicentric breast cancer: an exploratory organoid-based functional study.

Breast cancer research : BCR·2026
Same author

miR-203 facilitates timely cell fate transitions via epigenetic modulation during early embryogenesis.

Science advances·2026
Same author

Combination of Lurbinectedin Plus Irinotecan: Preclinical and Early Clinical Results in Patients With Relapsed SCLC.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2026
Same author

Real-world second- and third-line progression-free survival after progression on first-line CDK4/6 inhibitors in HR+/HER2- metastatic breast cancer by PAM50 intrinsic subtype: the SOLTI-1801 CDK-PREDICT study.

Breast cancer research and treatment·2026
Same author

Transient CB2 receptor activation triggers irreversible luminal differentiation via chromatin remodeling in breast cancer.

bioRxiv : the preprint server for biology·2025
Same journal

Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?

Trends in cell biology·2026
Same journal

Spindle errors: A stress test for epithelial robustness.

Trends in cell biology·2026
Same journal

Multicellular ecosystems: Linking cellular diversity to tissue function and disease.

Trends in cell biology·2026
Same journal

Orchestrating the signaling-bias at the protease-activated receptor, PAR1.

Trends in cell biology·2026
Same journal

Crashing by design: Utilizing DNA damage for MCC differentiation.

Trends in cell biology·2026
Same journal

The value of a shared lab: Our insights.

Trends in cell biology·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

661

Fueling the Cell Division Cycle.

María Salazar-Roa1, Marcos Malumbres1

  • 1Cell Division and Cancer group, Spanish National Cancer Research Centre (CNIO) Madrid, Spain.

Trends in Cell Biology
|October 18, 2016
PubMed
Summary
This summary is machine-generated.

Cell division requires significant energy. This review explores how cell division machinery controls cellular metabolism, including oxidative phosphorylation (OXPHOS) and glycolysis, impacting energy generation for crucial processes.

Keywords:
cell cycleenergyglycolysismetabolismoxidative phosphorylation

More Related Videos

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
11:23

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry

Published on: May 22, 2012

21.8K
Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

20.2K

Related Experiment Videos

Last Updated: Mar 13, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

661
Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
11:23

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry

Published on: May 22, 2012

21.8K
Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

20.2K

Area of Science:

  • Cell Biology
  • Metabolic Regulation
  • Cancer Biology

Background:

  • Cell division is an energy-intensive process.
  • The precise regulation of energy production for DNA synthesis and chromosome segregation remains unclear.
  • Mitochondrial dynamics and metabolic pathways (OXPHOS, glycolysis) are increasingly recognized to interact with cell division.

Purpose of the Study:

  • To review recent findings on the control of cellular metabolism by the cell division machinery.
  • To highlight the bidirectional relationship between cell division and metabolism.
  • To discuss the implications for human diseases, particularly cancer.

Main Methods:

  • Literature review of recent studies.
  • Analysis of the interplay between cell cycle machinery and metabolic pathways.
  • Examination of alterations in disease states.

Main Results:

  • Cell division machinery tightly regulates mitochondrial dynamics and metabolic pathways like OXPHOS and glycolysis.
  • Energy availability influences cell-cycle checkpoints, indicating a two-way connection.
  • Dysregulation of these metabolic controls is implicated in human diseases.

Conclusions:

  • The cell cycle machinery exerts significant control over cellular metabolism.
  • Understanding these metabolic regulatory mechanisms is crucial for developing therapeutic strategies for diseases like cancer.
  • Further research into the cell division-metabolism crosstalk is warranted.