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Multisite reliability of MR-based functional connectivity.

Stephanie Noble1, Dustin Scheinost2, Emily S Finn1

  • 1Yale University, Interdepartmental Neuroscience Program, New Haven, CT, USA.

Neuroimage
|October 18, 2016
PubMed
Summary
This summary is machine-generated.

Multisite functional connectivity MRI studies show poor reliability with short scans. Longer scan durations are essential for dependable results, especially in rare clinical populations.

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Psychiatry

Background:

  • Multisite functional connectivity MRI (fcMRI) studies accelerate data collection and increase sample sizes, particularly for rare clinical populations.
  • However, variability introduced by different sites and MRI scanners can limit study power and weaken findings.
  • Limited data exists on the stability of functional connectivity (FC) measurements across sites and sessions.

Purpose of the Study:

  • To assess the influence of site and session on resting-state FC measurements in healthy subjects.
  • To quantify contributions to FC variability from subject, site, and day-of-scan.
  • To evaluate between-session (test-retest) reliability using Generalizability Theory.

Main Methods:

  • Utilized a traveling subjects design with 8 healthy subjects scanned twice at each of 8 sites (North American Prodrome Longitudinal Study - NAPLS).
  • Investigated reliability using seed-based connectivity (PCC, RMC, LT), intrinsic connectivity distribution (ICD), and matrix connectivity.
  • Quantified variance components to assess reliability across different FC measures and scan durations.

Main Results:

  • Univariate FC analyses showed minimal site, scanner, or day-of-scan effects; subject effects were dominant.
  • Voxel-wise FC summaries were sensitive to site and scanner manufacturer effects.
  • Poor reliability (ICC=0.07-0.17) was observed for single 5-minute scans, increasing with scan duration (ICC=0.21-0.36 at 25min).

Conclusions:

  • Limited site and scanner effects support multisite studies for rare populations and univariate FC research.
  • High residual variance (60-80%) indicates significant scan-to-scan variability independent of measured factors.
  • Aggregation of fcMRI data across longer scan durations is necessary to enhance single-subject FC reliability.