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Transfer Hydrogenation in Water
Xiaofeng Wu1, Chao Wang2, Jianliang Xiao1,2
1Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.
This study details advancements in aqueous-phase transfer hydrogenation reactions. We developed asymmetric and achiral methods using novel catalysts for diverse substrates, advancing green chemistry.
Area of Science:
- Organic Chemistry
- Green Chemistry
- Catalysis
Background:
- Transfer hydrogenation is a key synthetic method.
- Developing environmentally friendly reaction conditions is crucial.
- Aqueous-phase reactions offer sustainability benefits.
Purpose of the Study:
- To report the development of aqueous-phase transfer hydrogenation reactions.
- To showcase asymmetric and achiral catalytic systems.
- To demonstrate substrate scope including carbonyl compounds and N-heterocycles.
Main Methods:
- Asymmetric transfer hydrogenation using Noyori-Ikariya catalysts in water.
- Achiral transfer hydrogenation employing novel iridacycle catalysts in water.
- Testing reactions with various carbonyl compounds and N-heterocycles.
Main Results:
- Successful asymmetric transfer hydrogenation in aqueous media.
- Efficient achiral transfer hydrogenation with iridacycle catalysts.
- Broad substrate applicability demonstrated for both methods.
Conclusions:
- Aqueous-phase transfer hydrogenation is feasible and effective.
- Noyori-Ikariya and iridacycle catalysts show promise for green synthesis.
- These methods provide sustainable routes to valuable organic compounds.
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