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An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
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Fabricating customized hydrogel contact lens.

Andre Childs1,2, Hao Li2, Daniella M Lewittes2

  • 1Department of Physics and Astronomy, University of Texas at San Antonio, San Antonio, TX, 78249, USA.

Scientific Reports
|October 18, 2016
PubMed
Summary
This summary is machine-generated.

Researchers developed a flexible method for creating custom hydrogel contact lenses for animal research. This technique offers a cost-effective and faster alternative to commercial options for in vivo imaging.

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Area of Science:

  • Biomaterials Science
  • Ophthalmology
  • Pre-clinical Research

Background:

  • Contact lenses are essential tools for in vivo animal retinal imaging and pre-clinical studies.
  • Customized lens shapes are often required for optimal fit on animal corneas.
  • Limited availability of commercially modified contact lenses poses a challenge.

Purpose of the Study:

  • To develop a flexible and efficient method for fabricating customized hydrogel contact lenses.
  • To characterize the optical and mechanical properties of the fabricated lenses.
  • To evaluate the performance of customized lenses in in vivo animal retinal imaging.

Main Methods:

  • Fabrication of hydrogel contact lenses using a flexible method.
  • Characterization of hydrogel transparency, refractive index, Young's modulus, and hydrophobicity.
  • Assessment of retinal imaging quality using optical coherence tomography in rats wearing customized lenses.

Main Results:

  • Fabricated hydrogel lenses exhibit high transparency with refractive indices from 1.42 to 1.45 (400-800 nm).
  • Young's modulus was measured at 1.47 MPa, and hydrophobicity showed a contact angle of 40.5°.
  • Retinal imaging quality with customized lenses was comparable to imaging without lenses.

Conclusions:

  • The developed method provides a cost-effective and time-efficient approach for producing customized soft contact lenses.
  • This technique can significantly benefit laboratorial use of contact lenses in pre-clinical studies.
  • Customized hydrogel contact lenses facilitate advanced in vivo animal retinal imaging.