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Published on: January 13, 2017
New milbemycin metabolites from the genetically engineered strain Streptomyces bingchenggensis BCJ60
Jian-Song Li1, Min-Na Du2, Hui Zhang2
1a Life Science and Biotechnology Research Center, School of Life Science , Northeast Agricultural University , Harbin , China.
Abstract:
Two new milbemycin derivatives, 27-methoxylmilbemycin α31 (1) and 27-oxomilbemycin α31 (2), were isolated from the genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined by 1D NMR, 2D NMR and HR-ESI-MS spectral analysis, and comparison with previous reports. The acaricidal and nematocidal capacities of compounds 1 and 2 were evaluated against Tetranychus cinnabarinus and Bursaphelenchus xylophilus, respectively. The results showed that the two new macrocyclic lactones 1 and 2 possessed potent acaricidal and nematocidal activities.
