Evaluation of extracapsular extension in prostate cancer using qualitative and quantitative multiparametric MRI

To investigate the value of multiparametric magnetic resonance imaging (mpMRI) for extracapsular extension (ECE) in prostate cancer (PCa).

In all, 292 patients who received radical prostatectomy and underwent preoperative mpMRI at 3T were enrolled retrospectively. For determining the associations with ECE, the likelihood of ECE was assessed qualitatively on T₂ -weighted imaging (T₂ WI) and combined T₂ WI and diffusion-weighted imaging (DWI) or dynamic contrast-enhanced imaging (DCEI). Quantitative MRI parameters were measured in PCa based on histopathological findings. Two models for detecting ECE including imaging and clinical parameters were developed using multivariate analysis: Model 1 excluding combined T₂ WI and DWI and DCEI and Model 2 excluding combined T₂ WI and DWI, and combined T₂ WI and DCEI. Diagnostic performance of imaging parameters and models was evaluated using the area under the receiver operating characteristics curve (Az).

For detecting ECE, the specificity, accuracy, and Az of combined T₂ WI and DWI or DCEI were statistically better than those of T₂ WI (P < 0.05), and all quantitative MRI parameters showed a statistical difference between the patients with and without ECE (P < 0.05). On multivariate analysis, significant independent markers in Model 1 were combined T₂ WI and DWI, combined T₂ WI and DCEI, and K^trans (P < 0.05). In Model 2, significant markers were combined T₂ WI and DWI and DCEI, K^trans , K_ep , and Ve (P < 0.05). The Az values of models 1 and 2 were 0.944 and 0.957, respectively.

mpMRI may be useful to improve diagnostic accuracy of the models for determining the associations with ECE in PCa.

4 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;45:1760-1770.