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The New Sepsis Definitions: Implications for the Basic and Translational Research Communities
Craig M Coopersmith1, Clifford S Deutschman
1*5E Surgical Intensive Care Unit, Emory Critical Care Center, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia †Department of Pediatrics, Hofstra-Northwell School of Medicine, Steven and Alexandra Cohen Children's Medical Center, New Hyde Park, New York ‡Feinstein Institute for Medical Research, Elmezzi Graduate School of Molecular Medicine, Manhasset, New York.
New sepsis and septic shock definitions from 2016 offer evidence-based clinical criteria for identifying at-risk patients, significantly impacting future sepsis research and clinical practice.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Clinical Research
Background:
- The definitions for sepsis and septic shock were last updated in 2001.
- Previous definitions lacked a strong evidence-based foundation for clinical criteria.
Purpose of the Study:
- To review the new definitions of sepsis and septic shock published in 2016.
- To explore the implications of these updated definitions for sepsis and septic shock research.
Main Methods:
- Review of the 2016 published papers on new sepsis and septic shock definitions.
- Analysis of the evidence-based clinical criteria presented in the new definitions.
Main Results:
- New, evidence-based clinical criteria for identifying patients with sepsis and septic shock have been established.
- These updated definitions are expected to significantly influence the direction of sepsis research.
Conclusions:
- The 2016 definitions represent a substantial advancement in the understanding and identification of sepsis and septic shock.
- Researchers and clinicians should adopt these new criteria to improve patient outcomes and advance scientific knowledge.
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