Related Experiment Videos
A rare malady with a rarer complication.
Arun Gopi1, Placid Sebastian1, C D Ramakrishna1
1Department of Cardiology, Sahakarna Hrudalaya, Pariyarum Medical College, Kannur, Kerala, India.
Indian Heart Journal
|October 19, 2016
Summary
Isolated ventricular noncompaction (IVNC) can cause heart failure. A rare case shows IVNC leading to coronary thromboembolism and myocardial infarction due to blood stasis, a previously undocumented complication.
Area of Science:
- Cardiology
- Pathophysiology
Background:
- Isolated ventricular noncompaction (IVNC) is a rare cardiomyopathy with prominent trabeculations and deep recesses.
- Myocardial infarction is uncommon in IVNC, typically linked to coronary artery disease, not intrinsic cardiac events.
Observation:
- A 19-year-old male presented with heart failure symptoms and severe left ventricular dysfunction due to IVNC.
- He developed an anterior wall ST-elevation myocardial infarction (STEMI) six months after initial diagnosis and treatment.
Findings:
- Coronary angiography revealed thrombotic occlusion of the left anterior descending artery (LAD).
- The occlusion was successfully treated with tirofiban and heparin, indicating a thromboembolic event.
- This represents the first documented case of coronary thromboembolism secondary to blood stasis in the left ventricle in IVNC.
Implications:
- This case highlights a novel mechanism of myocardial infarction in IVNC patients.
- It suggests that blood stasis in the noncompacted left ventricle may predispose to thromboembolism.
- Further research is needed to understand and manage this rare but serious complication of IVNC.
Related Concept Videos
01:23Rheumatic Heart Disease I: Introduction
735
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
735
01:17Chronic Bowel Disorders: Introduction
871
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
871
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
724
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
724
01:20Inborn Errors of Metabolism
985
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
985
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
1.3K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.3K
01:25Cardiomyopathy I: Introduction and Classification
748
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
748